The NFATC2/Nrf2 cascade regulates spinal cord ischemia-reperfusion injury by controlling inflammation, apoptosis and oxidative stress

The NFATC2/Nrf2 cascade regulates spinal cord ischemia-reperfusion injury by controlling inflammation, apoptosis and oxidative stress

Spinal cord ischemia/reperfusion (IR) injury (SCII) can cause major autonomic, sensory, and motor damage and loss. The upregulation of Nrf2, a primary orchestrator of the oxidative stress response, has beneficial effects in SCII. Here, we aimed to uncover a SCII-related transcription factor that is...

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Bibliographic Details
Main Authors: Kunbin Li, Liming Lu, Xianli Yao, Zhiyuan Wu, Pingge Sun, Xiaopeng Wen, Xiaoxing Li, Kai Wang, Xiran Yin
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Regenerative Therapy
Subjects:
Spinal cord ischemia/reperfusion (IR) injury
Inflammation
Oxidative stress
Nrf2
Transcription factor
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320424002074
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