Development and characterization of a fully humanized ACE2 mouse model

Development and characterization of a fully humanized ACE2 mouse model

Abstract Background Many humanized angiotensin-converting enzyme 2 (ACE2) mouse models of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection do not replicate human ACE2 protein expression and thus exhibit pathology infrequently observed in humans. To address this limitation, we d...

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Main Authors: Chunyu Ge, Amr R. Salem, Amany Elsharkawy, Janhavi Natekar, Anchala Guglani, Jaser Doja, Osarume Ogala, Gavin Wang, Susan H. Griffin, Orazio J. Slivano, Robin Shoemaker, Benard O. Ogola, Christopher F. Basler, Ajay Kumar, W. Bart Bryant, Mukesh Kumar, Joseph M. Miano
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Biology
Subjects:
ACE2
Angiotensin
CRISPR
Long noncoding RNA
Mouse
SARS-CoV-2
Online Access:https://doi.org/10.1186/s12915-025-02293-w
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https://doi.org/10.1186/s12915-025-02293-w

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