Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37)
Calcitonin, CGRP, adrenomedullin, and amylin require both CRLR (calcitonin-gene receptor like receptor) and receptor activity modifying proteins (RAMP1, RAMP2, and RAMP3) in different combinations for expression of selective, functional receptors[1]. We investigated whether the antagonists BIBN4096B...
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| Format: | Article |
| Language: | English |
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Wiley
2001-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2001.437 |
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| author | Z. Razzaque D. Shaw M. Bock L. Maskell J. Pickard D. Sirinathsinghji J. Longmore |
| author_facet | Z. Razzaque D. Shaw M. Bock L. Maskell J. Pickard D. Sirinathsinghji J. Longmore |
| author_sort | Z. Razzaque |
| collection | DOAJ |
| description | Calcitonin, CGRP, adrenomedullin, and amylin require both CRLR (calcitonin-gene receptor like receptor) and receptor activity modifying proteins (RAMP1, RAMP2, and RAMP3) in different combinations for expression of selective, functional receptors[1]. We investigated whether the antagonists BIBN4096BS[2], Compound 1 (WO98/11128, [3]), and CGRP(8-37) are functionally selective for CGRP receptors in human middle meningeal arteries (HMMA). |
| format | Article |
| id | doaj-art-6dffa562d4fd4df2bca066791a8923b4 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-6dffa562d4fd4df2bca066791a8923b42025-02-03T06:00:20ZengWileyThe Scientific World Journal1537-744X2001-01-011171710.1100/tsw.2001.437Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37)Z. Razzaque0D. Shaw1M. Bock2L. Maskell3J. Pickard4D. Sirinathsinghji5J. Longmore6Merck Sharp & Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, UKMerck Sharp & Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, UKMRL, Chemistry Department, West Point, PA, USANeurosurgery Unit, Addenbrookes Hospital, Hills Road, Cambridge, CB2 2QQ, UKNeurosurgery Unit, Addenbrookes Hospital, Hills Road, Cambridge, CB2 2QQ, UKMerck Sharp & Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, UKMerck Sharp & Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, UKCalcitonin, CGRP, adrenomedullin, and amylin require both CRLR (calcitonin-gene receptor like receptor) and receptor activity modifying proteins (RAMP1, RAMP2, and RAMP3) in different combinations for expression of selective, functional receptors[1]. We investigated whether the antagonists BIBN4096BS[2], Compound 1 (WO98/11128, [3]), and CGRP(8-37) are functionally selective for CGRP receptors in human middle meningeal arteries (HMMA).http://dx.doi.org/10.1100/tsw.2001.437 |
| spellingShingle | Z. Razzaque D. Shaw M. Bock L. Maskell J. Pickard D. Sirinathsinghji J. Longmore Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37) The Scientific World Journal |
| title | Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37) |
| title_full | Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37) |
| title_fullStr | Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37) |
| title_full_unstemmed | Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37) |
| title_short | Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37) |
| title_sort | study of cgrp receptors in human isolated middle meningeal arteries using bibn4096bs compound 1 and hαcgrp 8 37 |
| url | http://dx.doi.org/10.1100/tsw.2001.437 |
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