Poor glycaemic control in type 2 diabetes compromises leukocyte oxygen consumption rate, OXPHOS complex content and neutrophil-endothelial interactions

Poor glycaemic control in type 2 diabetes compromises leukocyte oxygen consumption rate, OXPHOS complex content and neutrophil-endothelial interactions

The mitochondrial electron transport chain becomes overloaded in type 2 diabetes (T2D), which increases ROS (Reactive Oxygen Species) production and impairs mitochondrial function. Peripheral blood mononuclear cells (PBMCs) are critical players in the inflammatory process that underlies T2D. Poor gl...

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Main Authors: Julia Cacace, Clara Luna-Marco, Alberto Hermo-Argibay, Catherine Pesantes-Somogyi, Omar A. Hernández-López, María Pelechá-Salvador, Celia Bañuls, Nadezda Apostolova, Luis de Miguel-Rodríguez, Carlos Morillas, Milagros Rocha, Susana Rovira-Llopis, Víctor M. Víctor
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Redox Biology
Subjects:
Type 2 diabetes
HbA1c
Mitochondria
OXPHOS
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725000291
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