Identification and validation of cellular senescence-related genes and immune cell infiltration characteristics in intervertebral disc degeneration

Identification and validation of cellular senescence-related genes and immune cell infiltration characteristics in intervertebral disc degeneration

ObjectiveTo identify cell senescence-related genes and immune cell infiltration characteristics in intervertebral disc degeneration (IVDD) using bioinformatics and investigate their biological functions and signaling pathways.MethodsGSE56081 and GSE23130 datasets were downloaded from the Gene Expres...

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Bibliographic Details
Main Authors: Hao Li, Lei Miao, Jiayuan Wu, Ye Wang, Jiyuan Xia, Da He
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
GEO database
intervertebral disc degeneration
cellular senescence
immune infiltration
MAPK1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1589849/full
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