Panobinostat potentiates adagrasib-induced cell death by triggering autophagy in human non-small cell lung cancer

Panobinostat potentiates adagrasib-induced cell death by triggering autophagy in human non-small cell lung cancer

Abstract Adagrasib, a KRASG12C inhibitor, recently received accelerated approval from the US FDA for the treatment of patients diagnosed with KRASG12C-mutated non-small cell lung cancer. Although adagrasib has demonstrated excellent clinical efficacy and good safety, the molecular mechanism underlyi...

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Main Authors: Hui Lu, Wenying Fu, Yiqun Xia, Ying Yan, Chongchong Shu, Yinghua Chen, Chenxin Xu, Peisen Zheng, Xin Shen, Ri Cui, Peng Zou, Daoyong Ni
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02657-9
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https://doi.org/10.1038/s41420-025-02657-9

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