PTEN deficiency in postnatally developing Purkinje cells disrupts metabolic signaling, leading to dendritic abnormalities and sex-specific behavioral deficits

PTEN deficiency in postnatally developing Purkinje cells disrupts metabolic signaling, leading to dendritic abnormalities and sex-specific behavioral deficits

Abstract Conditional deletion of the Pten gene in cerebellar Purkinje cells (PCs) results in cellular hypertrophy, neurodegeneration, and autism-like behaviors in adult mice. Here, we investigated the effects of PTEN conditional deficiency on PC dendritic development and early postnatal motor, spont...

Full description

Saved in:
Bibliographic Details
Main Authors: Lindsay J. Walsh, Izabella M. Espinal-San Miguel, Ana V. Rodriguez, Ursula M. Peña, Kiley E. Flynn, Will C. Remillard, Siena R. Brazier, Natalia I. Anderson, Aidan J. Clark, Tiffany A. De Varona, Ileana Soto
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
PTEN
Purkinje cells
mTORC1
Mitochondria
Lysosomes
AMPK
Online Access:https://doi.org/10.1038/s41598-025-09059-y
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-025-09059-y

Similar Items