Coronavirus RNA-dependent RNA polymerase interacts with the p50 regulatory subunit of host DNA polymerase delta and plays a synergistic role with RNA helicase in the induction of DNA damage response and cell cycle arrest in the S phase

Coronavirus RNA-dependent RNA polymerase interacts with the p50 regulatory subunit of host DNA polymerase delta and plays a synergistic role with RNA helicase in the induction of DNA damage response and cell cycle arrest in the S phase

Disruption of the cell cycle is a common strategy shared by many viruses to create a conducible cellular microenvironment for their efficient replication. We have previously shown that infection of cells with gammacoronavirus infectious bronchitis virus (IBV) activated the theataxia-telangiectasia m...

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Bibliographic Details
Main Authors: Li Quan, Xinxin Sun, Linghui Xu, Rui Ai Chen, Ding Xiang Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Emerging Microbes and Infections
Subjects:
Coronavirus
nsp12
DNA polymerase delta p50 subunit
interaction
cell cycle arrest
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2023.2176008
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https://www.tandfonline.com/doi/10.1080/22221751.2023.2176008

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