A comprehensive framework of E2–RING E3 interactions of the human ubiquitin–proteasome system

A comprehensive framework of E2–RING E3 interactions of the human ubiquitin–proteasome system

Abstract Covalent attachment of ubiquitin to substrates is crucial to protein degradation, transcription regulation and cell signalling. Highly specific interactions between ubiquitin‐conjugating enzymes (E2) and ubiquitin protein E3 ligases fulfil essential roles in this process. We performed a glo...

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Bibliographic Details
Main Authors: Sjoerd J L van Wijk, Sjoerd J de Vries, Patrick Kemmeren, Anding Huang, Rolf Boelens, Alexandre M J J Bonvin, H Th Marc Timmers
Format: Article
Language:English
Published: Springer Nature 2009-08-01
Series:Molecular Systems Biology
Subjects:
protein network
protein–protein interaction networks
ubiquitin‐conjugating enzymes
ubiquitin–protein ligases
yeast two‐hybrid
Online Access:https://doi.org/10.1038/msb.2009.55
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https://doi.org/10.1038/msb.2009.55

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