Macrophage Therapy for Acute Liver Injury (MAIL): a study protocol for a phase 1 randomised, open-label, dose-escalation study to evaluate safety, tolerability and activity of allogeneic alternatively activated macrophages in patients with paracetamol-induced acute liver injury in the UK

Macrophage Therapy for Acute Liver Injury (MAIL): a study protocol for a phase 1 randomised, open-label, dose-escalation study to evaluate safety, tolerability and activity of allogeneic alternatively activated macrophages in patients with paracetamol-induced acute liver injury in the UK

Introduction Acute liver failure (ALF) has no effective treatment other than liver transplantation and is commonly caused by paracetamol overdose. New treatments are needed to treat and prevent ALF. Alternatively-activated macrophages (AAMs) can promote resolution of liver necrosis and stimulate hep...

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Main Authors: Kim Walker, Joanna Moore, Fiona Mitchell, Alison Grant, Christopher J Weir, Ashley Jones, Guruprasad Aithal, Julia Boyd, James W Dear, Aryelly Rodriguez, Julia Grahamslaw, James Coulson, Stuart J Forbes, Angela Thomas, John D M Campbell, Christopher Humphries, Ellise Clarke, Ailsa Geddes, Sharon Zahra, Melisande Addison, Lesley Briody, Maria Elena Candela, Nicholas Downing-James, Robert John Fontana, Anna Heye, James A Hutchinson, Alice Riddell, Garry Tucker, Rachel Woods
Format: Article
Language:English
Published: BMJ Publishing Group 2024-12-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/14/12/e089417.full
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