Targeting the Type I Interferon Pathway in Glomerular Kidney Disease: Rationale and Therapeutic Opportunities

Targeting the Type I Interferon Pathway in Glomerular Kidney Disease: Rationale and Therapeutic Opportunities

Type I interferons (IFNs) are immunostimulatory molecules that can activate the innate and adaptive immune systems. In cases of immune dysfunction, prolonged activation of the type I IFN pathway has been correlated with kidney tissue damage in a wide range of kidney disorders, such as lupus nephriti...

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Bibliographic Details
Main Authors: James Tumlin, Brad Rovin, Hans-Joachim Anders, Eduardo F. Mysler, David R.W. Jayne, Tsutomu Takeuchi, Catharina Lindholm, Gudrun Weiss, Alessandro Sorrentino, Kevin Woollard, Nicola Ferrari
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Kidney International Reports
Subjects:
anifrolumab
immune dysfunction
interferon pathway
kidney disease
lupus nephritis
type I interferon
Online Access:http://www.sciencedirect.com/science/article/pii/S246802492401979X
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