The Development of an Age-Appropriate Fixed Dose Combination for Tuberculosis Using Physiologically-Based Pharmacokinetic Modeling (PBBM) and Risk Assessment

The Development of an Age-Appropriate Fixed Dose Combination for Tuberculosis Using Physiologically-Based Pharmacokinetic Modeling (PBBM) and Risk Assessment

<b>Background/Objectives:</b> The combination of isoniazid (INH) and rifampicin (RIF) is indicated for the treatment maintenance phase of tuberculosis (TB) in adults and children. In Brazil, there is no current reference listed drug for this indication in children. Farmanguinhos has unde...

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Bibliographic Details
Main Authors: Xavier J. H. Pepin, Juliana Johansson Soares Medeiros, Livia Deris Prado, Sandra Suarez Sharp
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceutics
Subjects:
tuberculosis
formulation
pediatrics
PBBM
safety
efficacy
Online Access:https://www.mdpi.com/1999-4923/16/12/1587
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