Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation

Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation

Abstract Gemcitabine combined with cisplatin is the first-line chemotherapy for advanced cholangiocarcinoma, but drug resistance remains a challenge, leading to unsatisfactory therapeutic effect. Here, we elucidate the possibility of chemotherapy regimens sensitized by inhibiting succinylation in pa...

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Main Authors: Ning Zhang, Linmao Sun, Shuo Zhou, Changyong Ji, Tianming Cui, Qi Chu, Jiareng Ye, Shuhang Liang, Kun Ma, Yufeng Liu, Xianying Li, Xinyu Guo, Weizhi Zhang, Xuetian Gu, Cheng Cheng, Qingrui Zha, Shengwei Tao, Yunguang Zhang, Junhui Chu, Chenghui Wu, Yuchen Zhang, Jiabei Wang, Yao Liu, Lianxin Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58429-7
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https://doi.org/10.1038/s41467-025-58429-7

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