Adjuvant dendritic cell-based immunotherapy in melanoma: insights into immune cell dynamics and clinical evidence from a phase II trial

Adjuvant dendritic cell-based immunotherapy in melanoma: insights into immune cell dynamics and clinical evidence from a phase II trial

Abstract Background Dendritic cells (DCs) are the most efficient antigen-presenting cells and play a central role in the immune system, orchestrating immune response against tumors. We previously demonstrated that DC-based vaccination effectively induces anti-tumor immunity, yet at the same time sho...

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Main Authors: Jenny Bulgarelli, Claudia Piccinini, Emanuela Scarpi, Giorgia Gentili, Laura Renzi, Silvia Carloni, Francesco Limarzi, Elena Pancisi, Anna Maria Granato, Massimiliano Petrini, Francesco De Rosa, Massimo Guidoboni, Dalila Fanelli, Maria Maddalena Tumedei, Marcella Tazzari, Stefano Baravelli, Ilaria Bronico, Pietro Cortesi, Sara Pignatta, Laura Capelli, Valentina Ancarani, Giovanni Foschi, Livia Turci, Francesca Tauceri, Massimo Framarini, Laura Ridolfi
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Subjects:
Dendritic cell
Immunotherapy
Skin cancer
Immune modulatory
Tumor microenvironment
Online Access:https://doi.org/10.1186/s12967-025-06403-8
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https://doi.org/10.1186/s12967-025-06403-8

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