Evaluating T-cell cross-reactivity between tumors and immune-related adverse events with TCR sequencing: pitfalls in interpretations of functional relevance

Evaluating T-cell cross-reactivity between tumors and immune-related adverse events with TCR sequencing: pitfalls in interpretations of functional relevance

T-cell receptor sequencing (TCRseq) enables tracking of T-cell clonotypes recognizing the same antigen over time and across biological compartments. TCRseq has been used to test if cross-reactive antitumor T cells are responsible for development of immune-related adverse events (irAEs) following imm...

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Main Authors: Jiajia Zhang, Franco Verde, Tricia Cottrell, Hans Hammers, Kellie N Smith, Janis Taube, Boyang Zhang, Genevieve J Kaunitz, Poromendro Burman, Hok-Yee Chan, Jody E Hooper, Mohamad E Allaf, Hongkai Ji
Format: Article
Language:English
Published: BMJ Publishing Group 2021-07-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/7/e002642.full
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https://jitc.bmj.com/content/9/7/e002642.full

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