Serine synthesis pathway regulates cardiac differentiation from human pluripotent stem cells

Serine synthesis pathway regulates cardiac differentiation from human pluripotent stem cells

Summary: Human pluripotent stem cell-derived cardiomyocyte (hPSC-CM) differentiation can improve using chemical compounds which mimic early heart development. However, variations in hPSC-CM differentiation efficiency and its poor reproducibility have remained a challenge. Here, we report a unique me...

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Main Authors: Tomohiko C. Umei, Shugo Tohyama, Yuika Morita-Umei, Manami Katoh, Seitaro Nomura, Kotaro Haga, Takako Hishiki, Tomomi Matsuura, Hidenori Tani, Yusuke Soma, Otoya Sekine, Masatoshi Ohno, Masashi Nakamura, Taijun Moriwaki, Yoshikazu Kishino, Keiichi Fukuda, Masaki Ieda
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:iScience
Subjects:
Biochemistry
Cell biology
Biological sciences research methodologies
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225011046
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http://www.sciencedirect.com/science/article/pii/S2589004225011046

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