Environmental enrichment alleviates neuropathic pain-associated anxiety by enhancing the function of parvalbumin interneurons in the anterior cingulate cortex

Environmental enrichment alleviates neuropathic pain-associated anxiety by enhancing the function of parvalbumin interneurons in the anterior cingulate cortex

Abstract Chronic neuropathic pain is often accompanied with comorbid anxiety. However, effective interventions for this anxiety are highly limited. This study aims to examine the effect of environmental enrichment (EE) on spared nerve injury (SNI)-induced neuropathic pain-associated anxiety behavior...

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Bibliographic Details
Main Authors: Zhuo-Yu Ren, Bao-Yu Han, Li-Yuan Zhao, Xue-Jie Lou, Yuan-Xiang Tao, Guang-Fen Zhang, Jian-Jun Yang
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Environmental enrichment
Neuropathic pain
PV interneurons
Gamma Oscillation
Online Access:https://doi.org/10.1038/s41598-025-95220-6
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https://doi.org/10.1038/s41598-025-95220-6

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