Long-Term Administration of Antioxidant N-Acetyl-L-Cysteine Impacts Beta Cell Oxidative Stress, Insulin Secretion, and Intracellular Signaling Pathways in Aging Mice

Long-Term Administration of Antioxidant N-Acetyl-L-Cysteine Impacts Beta Cell Oxidative Stress, Insulin Secretion, and Intracellular Signaling Pathways in Aging Mice

Research into the effects of long-term antioxidant supplementation on the islet microenvironment is limited. This study examined whether long-term N-acetyl-L-cysteine (NAC) supplementation can prevent changes in metabolic outcomes, beta cell function, and pancreatic stellate cell (PaSC) activation i...

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Bibliographic Details
Main Authors: Meg Schuurman, Jonathan Nguyen, Rachel B. Wilson, Malina Barillaro, Madison Wallace, Nica Borradaile, Rennian Wang
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Antioxidants
Subjects:
N-acetyl-L-cysteine (NAC)
beta cell oxidative stress
exocytosis proteins
pancreatic stellate cells (PaSCs)
collagen fiber
HFD-stress challenge
Online Access:https://www.mdpi.com/2076-3921/14/4/417
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