Extracellular Vesicles Derived From Streptococcus anginosus Aggravate Lupus Nephritis by Triggering TLR2‐MyD88‐NF‐κB Signalling in NK Cells

Extracellular Vesicles Derived From Streptococcus anginosus Aggravate Lupus Nephritis by Triggering TLR2‐MyD88‐NF‐κB Signalling in NK Cells

ABSTRACT Systemic lupus erythematosus (SLE) has been linked to gut microbiome dysbiosis, notably an overabundance of Streptococcus anginosus; however, the impact of this microbial imbalance on disease pathogenesis remains unclear. Here, we investigated the contribution of S. anginosus‐derived extrac...

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Main Authors: Ying Gong, Lingyue Jin, Lina Duan, Jie Xiao, Yao Li, HongXia Wang, Haifang Wang, Wanying Lin, Yi Zhang, Xiufeng Gan, Shuyin Pang, Yurong Qiu, Weinan Lai, Lei Zheng, Haixia Li
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Journal of Extracellular Vesicles
Subjects:
bacterial extracellular vesicle
lupus nephritis (LN)
natural killer cells (NK)
systemic lupus erythematosus (SLE)
TLR2‐ MyD88‐NF‐κB signalling
Online Access:https://doi.org/10.1002/jev2.70134
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https://doi.org/10.1002/jev2.70134

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