Ferulic acid inhibits ox-LDL-induced ferroptosis and apoptosis in RAW 264.7 cells via the HIF-1 signaling pathway

Ferulic acid inhibits ox-LDL-induced ferroptosis and apoptosis in RAW 264.7 cells via the HIF-1 signaling pathway

ObjectiveFerulic acid (FA) has shown potential in treating atherosclerosis (AS) by improving lipid metabolism and exerting anti-hypoxic effects. This study aimed to validate the mechanism of FA in AS through in vitro experiments.MethodsNetwork analysis was employed to predict the mechanisms underlyi...

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Bibliographic Details
Main Authors: Xize Wu, Xue Pan, Jian Kang, Yuxi Huang, Jiaqi Ren, Jiaxiang Pan, Kaifeng Yu, Yue Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
the HIF-1 signaling pathway
mitochondrion
lipid metabolism
cell death
ferulic acid
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1524736/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1524736/full

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