Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production.

Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production.

<h4>Background</h4>Thymocyte expressed molecule involved in selection 1 (Themis1, SwissProt accession number Q8BGW0) is the recently characterised founder member of a novel family of proteins. A second member of this family, Themis2 (Q91YX0), also known as ICB1 (Induced on contact with b...

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Main Authors: Matthew J Peirce, Matthew Brook, Nicholas Morrice, Robert Snelgrove, Shajna Begum, Alessandra Lanfrancotti, Clare Notley, Tracy Hussell, Andrew P Cope, Robin Wait
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011465&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011465&type=printable

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