Therapeutic potential of a rhein-loaded self-nano-emulsifying drug delivery system in ameliorating LPS-induced depression: mechanistic insights and behavioral outcomes

Therapeutic potential of a rhein-loaded self-nano-emulsifying drug delivery system in ameliorating LPS-induced depression: mechanistic insights and behavioral outcomes

Depression is a multifaceted disorder caused by neuroinflammation, which is mainly demarcated by a significant increase in proinflammatory cytokines, including interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). Conventional treatments for depression typically focus on...

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Main Authors: Sachin More, Md Abdur Rashid, Prashant Kumar Tiwari, Rohini Kharwade, Yahya Alhamhoom, Turky Omar Asar, Mohammed Kaleem, Nilesh Mahajan, Ajay Pise, Kishor Danao, Sanjay Kumar
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
rhein
self-nano-emulsified drug delivery system
neuroinflammation
depression
cytokines
lipopolysaccharides
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1577080/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1577080/full

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