Decoding mechanosensitive genes in cardiac fibroblasts via 3D hydrogel models of fibrosis

Decoding mechanosensitive genes in cardiac fibroblasts via 3D hydrogel models of fibrosis

Abstract Cardiac fibrosis arises from the abnormal activation of cardiac fibroblasts (CFs) in response to both chemical and mechanical stressors. While extracellular matrix (ECM) stiffness is a key determinant of fibroblast behavior, the molecular mechanisms linking mechanical signals to gene expres...

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Bibliographic Details
Main Authors: Heng Chen, Yuxiao Chen, Jinan Yang, Peng Yang, Hongqiang Cheng, Xiaogang Guo
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Cardiac fibrosis
Mechanosensitive genes
Extracellular matrix stiffness
RNA sequencing
Single-cell RNA sequencing
Online Access:https://doi.org/10.1038/s41598-025-16708-9
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https://doi.org/10.1038/s41598-025-16708-9

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