Neutrophils-mediated accelerated blood clearance phenomenon in beagles and rats based on the cross-injection of non-PEGylated and PEGylated nanoemulsions

Neutrophils-mediated accelerated blood clearance phenomenon in beagles and rats based on the cross-injection of non-PEGylated and PEGylated nanoemulsions

The initial injection of PEGylated nanoparticles can activate antibodies and the complement system, leading to the accelerated blood clearance (ABC) phenomenon, characterized by reduced circulation time and abnormal liver and spleen accumulation upon re-exposure. However, PEGylation is not essential...

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Bibliographic Details
Main Authors: Mengyang Liu, Jia Wang, Ge Chen, Lirong Wang, Xuling Wang, Bai Xiang, Yihui Deng, Chaoxing He, Lei Wang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:International Journal of Pharmaceutics: X
Subjects:
Non-PEGylated nanoparticles
Cross-injection
Accelerated blood clearance phenomenon
Neutrophils
Species difference
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156725000039
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