Characterization of hepatocarcinoma cells: lymphatic metastasis potential through enhanced production, expression, and secretion along the VEGF-C/D-VEGFR-3/NRP-2 axis

Characterization of hepatocarcinoma cells: lymphatic metastasis potential through enhanced production, expression, and secretion along the VEGF-C/D-VEGFR-3/NRP-2 axis

Abstract Objectives In vitro and in vivo analyses were conducted to examine the correlations between the production, expression, and secretion of the VEGF-C/D-VEGFR-3/NRP-2 axis and various levels of lymphatic metastatic potential in murine hepatocellular carcinoma cells. Methods Quantitative real-t...

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Bibliographic Details
Main Authors: Jingwen Wang, Xuejiao Qian, Zhiqi Yin, Dan Tong, Caihong Wang, Zhandong Hu, Wenjuan Cai, Jianwu Tang
Format: Article
Language:English
Published: Springer 2025-02-01
Series:Discover Oncology
Subjects:
Co-expression
Co-production
Co-secretion
Hepatocarcinoma
NRP-2
Tumor lymphatic metastasis
Online Access:https://doi.org/10.1007/s12672-025-01901-z
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https://doi.org/10.1007/s12672-025-01901-z

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