Vitamin D and omega-3 fatty acids attenuate MSG-induced neurodegeneration by modulating tau pathology, neuroinflammation, and VDR expression in rats

Vitamin D and omega-3 fatty acids attenuate MSG-induced neurodegeneration by modulating tau pathology, neuroinflammation, and VDR expression in rats

Abstract Monosodium glutamate (MSG)-induced excitotoxicity is a major factor contributing to cognitive decline and neurodegeneration. Given the well-established roles of vitamin D (Vit D) and omega-3 polyunsaturated fatty acids (N-3 PUFAs), especially eicosapentaenoic acid (EPA) and docosahexaenoic...

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Bibliographic Details
Main Authors: Rasha Z. Alshahawy, Sally M. Safwat, Sanad S. El-Kholy, Soheir F. El-basiony, Sara El-Desouky, Soheir M. Helmi
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
MSG
Vitamin D
Omega-3 PUFAs
VDRs
Neuroinflammation
Tau pathology
Online Access:https://doi.org/10.1038/s41598-025-06109-3
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https://doi.org/10.1038/s41598-025-06109-3

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