Behavior of test specificity under an imperfect gold standard: findings from a simulation study and analysis of real-world oncology data
Abstract Background Gold standards used in validation of new tests may be imperfect, with sensitivity or specificity less than 100%. The impact of imperfection in a gold standard on measured test attributes has been demonstrated formally, but its relevance in real-world oncology research may not be...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-05-01
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| Series: | BMC Medical Research Methodology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12874-025-02603-4 |
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