Hypoxia Impairs NK Cell Cytotoxicity through SHP-1-Mediated Attenuation of STAT3 and ERK Signaling Pathways

Hypoxia Impairs NK Cell Cytotoxicity through SHP-1-Mediated Attenuation of STAT3 and ERK Signaling Pathways

Natural killer (NK) cells are innate immune effectors with potent antitumor activity. However, tumor cells can create an immunosuppressive microenvironment to escape immune surveillance. Although accumulating evidence indicates that microenvironmental hypoxia plays an important role in favoring tumo...

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Main Authors: Rui Teng, Yanmeng Wang, Nan Lv, Dan Zhang, Ramone A. Williamson, Lei Lei, Ping Chen, Li Lei, Baiyan Wang, Jiaqi Fu, Xuna Liu, Aili He, Michael O’Dwyer, Jinsong Hu
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2020/4598476
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http://dx.doi.org/10.1155/2020/4598476

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