Shape memory bone screws loading L-arginine and Ca2+ propagate mechanical stimulation, energize bone cells and augment bone regeneration

Shape memory bone screws loading L-arginine and Ca2+ propagate mechanical stimulation, energize bone cells and augment bone regeneration

Metallic bone screws are clinically used to fix the fractured bone fragments in bone defect treatment; yet they present compromised therapeutic efficacy due to poor osseointegration and tissue support. Here, we develop a novel thermoresponsive shape memory (SMP) bone screw with osteogenesis-angiogen...

Full description

Saved in:
Bibliographic Details
Main Authors: Huaqian Liu, Weiwei Zhao, Yuhe Yang, Ho-Pan Bei, Qunchao Chen, Xintong Zhou, Yuanchi Zhang, Chunyi Wen, Yuefeng Hao, Jinlian Hu, Yaxiong Liu, Yu Zhang, Ka-Hing Wong, Hongyu Zhang, Xin Zhao
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-11-01
Series:Bioactive Materials
Subjects:
Bone screws
Shape memory effect
NO-cGMP signaling pathway
Calcium signaling pathway
Osteogenesis-angiogenesis coupling
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25003007
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2452199X25003007

Similar Items