Repurposing of the small-molecule adrenoreceptor-inhibitor carvedilol for treatment of the fibrotic lung

Repurposing of the small-molecule adrenoreceptor-inhibitor carvedilol for treatment of the fibrotic lung

IntroductionIdiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease with high mortality. Current therapies are very limited, with nintedanib and pirfenidone being the only non-invasive but non-curative interventions, ultimately bridging to lung transplantation.MethodsIn silico modelin...

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Main Authors: Maria Jordan, Kevin Schmidt, Maximilian Fuchs, Annette Just, Angelika Pfanne, Lena Willmer, Lavinia Neubert, Christopher Werlein, Patrick Zardo, Andreas Pich, Thomas Thum, Jan Fiedler
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
carvedilol
idiopathic pulmonary fibrosis
fibroblast
precision-cut lung slices
drug repurposing
miR-21
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1534989/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1534989/full

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