Bidirectional causal relationship between obesity and osteoarthritis: Insights from a two-sample Mendelian randomization study

Bidirectional causal relationship between obesity and osteoarthritis: Insights from a two-sample Mendelian randomization study

Objective: Osteoarthritis (OA) is a prevalent chronic disease associated with disability worldwide, and obesity is a key modifiable risk factor for OA. The study's aim was to investigate the causal relationship between obesity and OA. Method: This study employed a two-sample Mendelian randomiza...

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Main Authors: Anne Kamps, Jos Runhaar, Katerina Trajanoska, William D. Thompson, Weiya Zhang, Bahar Sedaghati-khayat, Joyce B.J. van Meurs, Sita M.A. Bierma-Zeinstra
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Osteoarthritis and Cartilage Open
Online Access:http://www.sciencedirect.com/science/article/pii/S266591312500072X
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