Direct visualization of chimeric antigen receptors on primary human T cells using dSTORM super-resolution microscopy

Direct visualization of chimeric antigen receptors on primary human T cells using dSTORM super-resolution microscopy

Chimeric antigen receptor (CAR) T cells are a transformative treatment for hematological malignancies, and concerted efforts in the field are aiming to translate this success to solid tumors and autoimmune diseases. There is a desire in the field to accurately assess CAR organization and spatiotempo...

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Bibliographic Details
Main Authors: Leon Gehrke, Nicole Seifert, Peter Spieler, Christina Verbruggen, Rick Seifert, Fabio Toppeta, Maximilian Krick, Sören Doose, Hermann Einsele, Michael Hudecek, Markus Sauer, Thomas Nerreter
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
CAR-T cell
immunotherapy
dSTORM
imaging
microscopy
CAR (chimeric antigen receptor)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1632823/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1632823/full

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