Targeting EGR1-ATF3 signaling mitigates paravertebral muscle degeneration by regulating cell death and inflammaging

Targeting EGR1-ATF3 signaling mitigates paravertebral muscle degeneration by regulating cell death and inflammaging

Abstract The paravertebral muscles play a critical role in maintaining dynamic spinal stability and physiological function. With aging, these muscles undergo senescence and degeneration, contributing to spinal instability and the development of low back pain. Age-related cellular death further accel...

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Bibliographic Details
Main Authors: Xuke Wang, Qingfeng Wang, Zhe Wang, Yingjie Zhou, Xiaobing Jiang, Yongjin Li
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Biological Research
Subjects:
Paravertebral muscle degeneration
EGR1-ATF3 signaling
Inflammaging
Cell death
RNA sequencing
Online Access:https://doi.org/10.1186/s40659-025-00634-1
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https://doi.org/10.1186/s40659-025-00634-1

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