CXCL16 Producing Tumor Clones Are Shaping Immunosuppressive Microenvironment in Squamous Cell Carcinoma via CXCR6 Regulatory T Cell

CXCL16 Producing Tumor Clones Are Shaping Immunosuppressive Microenvironment in Squamous Cell Carcinoma via CXCR6 Regulatory T Cell

ABSTRACT Background Cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) are the most prevalent types of nonmelanoma skin cancer (NMSC) and exhibit significant inter‐ and intra‐tumor heterogeneity. cSCC has a higher metastatic potential than BCC, accompanied by a considerable mort...

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Main Authors: Hyun Seung Choi, Sunyoung Jung, Ki‐Myo Kim, Mihyun Lee, Jun Ho Park, Sanha Hwang, Seung Min Cha, Jade N. Young, Dina Poplausky, Hyunsung Nam, Nicholas Gulati, Chung‐Gyu Park, Hyun Je Kim, Ji‐Ung Park
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Cancer Medicine
Subjects:
basal cell carcinoma
cutaneous squamous cell carcinoma
scRNA and TCR seq
spatial transcriptomic
Online Access:https://doi.org/10.1002/cam4.71060
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https://doi.org/10.1002/cam4.71060

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