Translation suppresses exogenous target RNA-mediated microRNA decay

Translation suppresses exogenous target RNA-mediated microRNA decay

Abstract MicroRNAs (miRNAs) interact with the target mRNAs to induce translational repression and mRNA degradation. Interestingly, miRNAs themselves can turnover rapidly when binding to a target RNA with extensive complementarity, a phenomenon called target-directed miRNA degradation (TDMD). To date...

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Main Authors: Tianqi Li, Lu Li, Nicholas M. Hiers, Peike Sheng, Yuzhi Wang, Conner M. Traugot, Jessi F. Effinger-Morris, Pitchaporn Akaphan, Yanyan Liu, Jiang Bian, Kotaro Fujii, Mingyi Xie
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60374-4
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https://doi.org/10.1038/s41467-025-60374-4

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