The human cytomegalovirus protein UL147A downregulates the most prevalent MICA allele: MICA*008, to evade NK cell-mediated killing.

The human cytomegalovirus protein UL147A downregulates the most prevalent MICA allele: MICA*008, to evade NK cell-mediated killing.

Natural killer (NK) cells are innate immune lymphocytes capable of killing target cells without prior sensitization. One pivotal activating NK receptor is NKG2D, which binds a family of eight ligands, including the major histocompatibility complex (MHC) class I-related chain A (MICA). Human cytomega...

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Bibliographic Details
Main Authors: Einat Seidel, Liat Dassa, Corinna Schuler, Esther Oiknine-Djian, Dana G Wolf, Vu Thuy Khanh Le-Trilling, Ofer Mandelboim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-05-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1008807&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1008807&type=printable

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