Periplocin induces necroptosis in papillary thyroid carcinoma through DR4 mediated RIPK3 and MLKL signaling

Periplocin induces necroptosis in papillary thyroid carcinoma through DR4 mediated RIPK3 and MLKL signaling

Abstract Periplocin, a tumor-inhibitory compound derived from Cortex periploca, was investigated for its mechanisms of action and therapeutic potential against human papillary thyroid carcinoma cell proliferation. BCPAP/TPC-1 cells were treated with periplocin ± necrostatin-1 (a necroptosis inhibito...

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Bibliographic Details
Main Authors: Li Ding, Fengmei Wen, Liang Zeng, Ziwei Li, Gangyin Xie
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Periplocin
Cell proliferation
Necroptosis
Papillary thyroid carcinoma
Death receptor 4 (DR4)
Online Access:https://doi.org/10.1038/s41598-025-08977-1
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