Periplocin induces necroptosis in papillary thyroid carcinoma through DR4 mediated RIPK3 and MLKL signaling
Abstract Periplocin, a tumor-inhibitory compound derived from Cortex periploca, was investigated for its mechanisms of action and therapeutic potential against human papillary thyroid carcinoma cell proliferation. BCPAP/TPC-1 cells were treated with periplocin ± necrostatin-1 (a necroptosis inhibito...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-08977-1 |
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