Tanshinone I promotes angiogenesis and improves ventricular remodeling post-myocardial infarction via ALDH2 signaling-mediated ferroptosis inhibition

BackgroundTanshinone I (Tan I) has diverse cardioprotective effects, including improving post-myocardial infarction (MI) ventricular remodeling. Ventricular remodeling can be improved by inhibiting endothelial cell (EC) ferroptosis to promote post-MI angiogenesis, but how Tan I does this remains unc...

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Bibliographic Details
Main Authors: Feng Zhang, Lei Li, Qian Liu, Wen-Long Wang, Zhi-Xin Wang, Rong-Qiang Song, Jian Sun, Yi-Yi Zhang, Xin-Chen Ren, Dong Wang, Yu-Ting Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1601017/full
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