Human Tyrosinase Displayed on the Surface of Chinese Hamster Ovary Cells for Ligand Fishing of Tyrosinase Inhibitors from Medicinal Plants

Human Tyrosinase Displayed on the Surface of Chinese Hamster Ovary Cells for Ligand Fishing of Tyrosinase Inhibitors from Medicinal Plants

Ligand fishing is a promising strategy for the screening of active ingredients from complex natural products. In this work, human tyrosinase (hTYR) was displayed on the surface of Chinese hamster ovary (CHO) cells for the first time; it was then used as bait to develop a new method for ligand fishin...

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Bibliographic Details
Main Authors: Xiao-Rui Zhai, Ming-Jie Li, Xiang Yin, Ayzohra Ablat, Yuan Wang, Peng Shu, Xun Liao
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Molecules
Subjects:
cell surface display
Chinese hamster ovary cells
tyrosinase inhibitors
<i>Alhagi sparsifolia</i>
<i>Coffea arabica</i>
B16 melanoma cells
Online Access:https://www.mdpi.com/1420-3049/30/1/30
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