N-glycosylation of PD-L1 modulates the efficacy of immune checkpoint blockades targeting PD-L1 and PD-1

Abstract Background The PD-L1/PD-1 pathway is crucial for immune regulation and has become a target in cancer immunotherapy. However, in order to improve patient selection for immune checkpoint blockade (ICB) therapies, better selection criteria are needed. This study explores how the N-glycosylatio...

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Main Authors:	Bar Kaufman, Muhammad Abu-Ahmad, Olga Radinsky, Eman Gharra, Tal Manko, Baisali Bhattacharya, Daniela Gologan, Nofar Erlichman, Tsipi Meshel, Yoav Nuta, Tomer Cooks, Moshe Elkabets, Adit Ben-Baruch, Angel Porgador
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Series:	Molecular Cancer
Subjects:	PD-L1 PD-1 N-glycosylation Inhibitory immune checkpoints T-cell activation Cancer immunotherapy
Online Access:	https://doi.org/10.1186/s12943-025-02330-w
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N-glycosylation of PD-L1 modulates the efficacy of immune checkpoint blockades targeting PD-L1 and PD-1

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