N-glycosylation of PD-L1 modulates the efficacy of immune checkpoint blockades targeting PD-L1 and PD-1

N-glycosylation of PD-L1 modulates the efficacy of immune checkpoint blockades targeting PD-L1 and PD-1

Abstract Background The PD-L1/PD-1 pathway is crucial for immune regulation and has become a target in cancer immunotherapy. However, in order to improve patient selection for immune checkpoint blockade (ICB) therapies, better selection criteria are needed. This study explores how the N-glycosylatio...

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Main Authors: Bar Kaufman, Muhammad Abu-Ahmad, Olga Radinsky, Eman Gharra, Tal Manko, Baisali Bhattacharya, Daniela Gologan, Nofar Erlichman, Tsipi Meshel, Yoav Nuta, Tomer Cooks, Moshe Elkabets, Adit Ben-Baruch, Angel Porgador
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Cancer
Subjects:
PD-L1
PD-1
N-glycosylation
Inhibitory immune checkpoints
T-cell activation
Cancer immunotherapy
Online Access:https://doi.org/10.1186/s12943-025-02330-w
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https://doi.org/10.1186/s12943-025-02330-w

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