CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy.

CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy.

Synonymous recoding of RNA virus genomes is a promising approach for generating attenuated viruses to use as vaccines. Problematically, recoding typically hinders virus growth, but this may be rectified using CpG dinucleotide enrichment. CpGs are recognised by cellular zinc-finger antiviral protein...

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Main Authors: Colin P Sharp, Beth H Thompson, Tessa J Nash, Ola Diebold, Rute M Pinto, Luke Thorley, Yao-Tang Lin, Samantha Sives, Helen Wise, Sara Clohisey Hendry, Finn Grey, Lonneke Vervelde, Peter Simmonds, Paul Digard, Eleanor R Gaunt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-05-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011357&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011357&type=printable

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