In vivo protein half-life analysis identifies the SREBF1-SLC27a5 axis governs antioxidant response in preclinical alcoholic rat model

In vivo protein half-life analysis identifies the SREBF1-SLC27a5 axis governs antioxidant response in preclinical alcoholic rat model

Background: ALD causes liver dysfunction with inflammation, steatosis, and fibrosis. While abstinence reverses damage, its effect on protein half-lives remains unclear. This study examines site-specific protein half-life changes, transcription regulation, and recovery mechanisms. Method: Long-Evans...

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Main Authors: Nupur Sharma, Sadam H. Bhat, Shweta Chaudhary, Babu Mathew, Sushmita Pandey, Sanju Yadav, Manisha Yadav, Vasundhra Bindal, Gaurav Tripathi, Neha Sharma, Vipul Sharma, Abhishak Gupta, Ranjan Nanda, Anupama Kumari, Shvetank Sharma, Jaswinder Singh Maras
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
Protein turnover
Half-life
Alcohol-associated liver disease
ALD rat model
Proteomics
Alcohol abstinence
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001879
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