Chondrocyte-specific knockout of Piezo1 and Piezo2 protects against post-traumatic osteoarthritis structural damage and pain in mice

Chondrocyte-specific knockout of Piezo1 and Piezo2 protects against post-traumatic osteoarthritis structural damage and pain in mice

Abstract Background Osteoarthritis (OA) is a debilitating joint disease characterized by cartilage degeneration, synovial inflammation, and bone remodeling, with limited therapeutic options targeting the underlying pathophysiology. Mechanosensitive ion channels Piezo1 and Piezo2 play crucial roles i...

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Main Authors: Erica V. Ely, Kristin L. Lenz, Sophie G. Paradi, Seth Ack, Abraham Behrmann, Sarah Dunivan, Lauryn Braxton, Wolfgang Liedtke, Yong Chen, Kelsey H. Collins, Farshid Guilak
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Arthritis Research & Therapy
Subjects:
Mechanosensitive ion channels
Pain modulation
DMOADs
Mechanotransduction
Subchondral bone
Meniscus
Online Access:https://doi.org/10.1186/s13075-025-03620-w
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https://doi.org/10.1186/s13075-025-03620-w

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