Mitofilin–mtDNA Axis Mediates Chronic Lead Exposure-Induced Synaptic Plasticity Impairment of Hippocampal and Cognitive Deficits

Mitofilin–mtDNA Axis Mediates Chronic Lead Exposure-Induced Synaptic Plasticity Impairment of Hippocampal and Cognitive Deficits

Neurotoxic damage resulting from lead pollution exposure constitutes a significant public health concern. The regulatory impact of lead (Pb) exposure on neuronal dendritic spine plasticity, a crucial mechanism for neuronal adaptation, warrants further investigation. To elucidate the role and mechani...

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Bibliographic Details
Main Authors: Lihong Su, Jinchao Hou, Boxuan Wang, Yuqi Li, Xiaodong Huo, Tao Wang, Yuankang Zou, Gang Zheng
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Biomolecules
Subjects:
lead exposure
mitofilin
mtDNA
neuron
synaptic plasticity
Online Access:https://www.mdpi.com/2218-273X/15/2/272
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