Molecular docking and molecular dynamics simulations reveal the clinical resistance of the gatekeeper mutation V564F of FGFR2 against Infigratinib

Molecular docking and molecular dynamics simulations reveal the clinical resistance of the gatekeeper mutation V564F of FGFR2 against Infigratinib

Fibroblast growth factor receptor 2 (FGFR2), as a transmembrane receptor tyrosine kinase, is implicated in a plethora of human cancers, including intrahepatic cholangiocarcinomas, breast cancers, and non-small cell lung cancer. The clinically relevant V564F gatekeeper mutation conferred resistance t...

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Bibliographic Details
Main Authors: Guodong Zheng, Wuxia Liu, Qian Zhang, Tuo Shen, Jingfeng Zhang, Lei Jiang, Wenqi Liang, Bin Zhou, Ling Liu, Shenqian Xu, Minyu Li
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Experimental Nanoscience
Subjects:
FGFR2
Infigratinib
gatekeeper mutation
molecular dynamics simulations
binding free energy calculations
Online Access:https://www.tandfonline.com/doi/10.1080/17458080.2023.2264521
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https://www.tandfonline.com/doi/10.1080/17458080.2023.2264521

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