The phosphorylation of Smad3 by CaMKIIγ leads to the hepatocyte pyroptosis under perfluorooctane sulfonate exposure

The phosphorylation of Smad3 by CaMKIIγ leads to the hepatocyte pyroptosis under perfluorooctane sulfonate exposure

Perfluorooctane sulfonate (PFOS) is a persistent organic pollutant and accumulated in the liver of mammals. PFOS exposure is closely associated with the development of pyroptosis. Nevertheless, the underlying mechanism is unclear. We found here that PFOS induced pyroptosis in the mice liver and L-02...

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Bibliographic Details
Main Authors: Siyu Ren, Peiyao Liang, Ruzhen Feng, Wei Yang, Tianming Qiu, Jingyuan Zhang, Qiujuan Li, Guang Yang, Xiance Sun, Xiaofeng Yao
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Perfluorooctane sulfonate
Pyroptosis
Cytoplasmic calcium
Calcium/calmodulin-dependent protein kinase II γ
Smad family member 3
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324010005
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