Fungal Als proteins hijack host death effector domains to promote inflammasome signaling

Fungal Als proteins hijack host death effector domains to promote inflammasome signaling

Abstract High-damaging Candida albicans strains tend to form hyphae and exacerbate intestinal inflammation in ulcerative colitis patients through IL-1β-dependent mechanisms. Fungal agglutinin-like sequence (Als) proteins worsen DSS-induced colitis in mouse models. FADD and caspase-8 are important re...

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Bibliographic Details
Main Authors: Tingting Zhou, Norma V. Solis, Michaela Marshall, Qing Yao, Eric Pearlman, Scott G. Filler, Haoping Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56657-5
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https://doi.org/10.1038/s41467-025-56657-5

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