BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

Abstract Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous acetaldehyde, a product of cellular metabolism, is a potent source of DNA damage, particularly toxic to cells and mice lacking the FA p...

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Main Authors: Eliana MC Tacconi, Xianning Lai, Cecilia Folio, Manuela Porru, Gijs Zonderland, Sophie Badie, Johanna Michl, Irene Sechi, Mélanie Rogier, Verónica Matía García, Ankita Sati Batra, Oscar M Rueda, Peter Bouwman, Jos Jonkers, Anderson Ryan, Bernardo Reina‐San‐Martin, Joannie Hui, Nelson Tang, Alejandra Bruna, Annamaria Biroccio, Madalena Tarsounas
Format: Article
Language:English
Published: Springer Nature 2017-07-01
Series:EMBO Molecular Medicine
Subjects:
BRCA1
BRCA2
disulfiram, acetaldehyde dehydrogenase
DNA damage
replication stress
Online Access:https://doi.org/10.15252/emmm.201607446
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https://doi.org/10.15252/emmm.201607446

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